Mechanism of sustained drug release in diffusion-controlled polymer matrix-application of percolation theory
نویسندگان
چکیده
This paper dealt with the controlled release of two kinds of drugs, 5-fluorouracil (5-FU) and hydrocortisonum (Hydro.) and loaded poly(ethylene-vinylalcohol) (EVAL), which composed 5-FU/EVAL and Hydro./EVAL matrix systems. The results were analyzed using the pseudo-steady-diffusion models coupled with the fundamental concepts of percolation theory. The percolation thresholds for the two systems were calculated, which could indicate the contribution of pore and matrix diffusion in controlled drug release. © 1998 Elsevier Science B.V. All rights reserved.
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